Multiple Alignment of Continuous Time Series

Jennifer Listgarten, Radford M. Neal, Sam T. Roweis, Andrew Emili

Multiple realizations of continuous-valued time series from a stochastic process often contain systematic variations in rate and amplitude. To leverage the information contained in such noisy replicate sets, we need to align them in an appropriate way (for example, to allow the data to be properly combined by adaptive averaging). We present the Continuous Profile Model (CPM), a generative model in which each observed time series is a non-uniformly subsampled version of a single latent trace, to which local rescaling and additive noise are applied. After unsupervised training, the learned trace represents a canonical, high resolution fusion of all the replicates. As well, an alignment in time and scale of each observation to this trace can be found by inference in the model. We apply CPM to successfully align speech signals from multiple speakers and sets of Liquid Chromatography - Mass Spectrometry (LC-MS) proteomic data.

In L. K. Saul, et al (editors), Advances in Neural Information Processing Systems 17 (aka NIPS*2004), MIT Press, 8 pages: postscript, pdf.

Also available via the NIPS site